The enteric nervous system promotes intestinal health by constraining microbiota composition.

The enteric nervous system promotes intestinal health by constraining microbiota composition.

Blog Article

Sustaining a balanced intestinal microbial community is critical for maintaining intestinal health and kicker pro comp 10 preventing chronic inflammation.The gut is a highly dynamic environment, subject to periodic waves of peristaltic activity.We hypothesized that this dynamic environment is a prerequisite for a balanced microbial community and that the enteric nervous system (ENS), a chief regulator of physiological processes within the gut, profoundly influences gut microbiota composition.We found that zebrafish lacking an ENS due to a mutation in the Hirschsprung disease gene, sox10, develop microbiota-dependent inflammation that is transmissible between hosts.

Profiling microbial here communities across a spectrum of inflammatory phenotypes revealed that increased levels of inflammation were linked to an overabundance of pro-inflammatory bacterial lineages and a lack of anti-inflammatory bacterial lineages.Moreover, either administering a representative anti-inflammatory strain or restoring ENS function corrected the pathology.Thus, we demonstrate that the ENS modulates gut microbiota community membership to maintain intestinal health.